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Overview

Keeping Up with the Evolving Treatment Landscape for Advanced/Metastatic Gastric/GEJ Cancer: Modeling Center of Excellence Practices

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Activity URL:

https://www.achlcme.org/detail/5060/Keeping-Up-with-the-Evolving-Treatment-Landscape-for-Ad...

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Keeping Up with the Evolving Treatment Landscape for Advanced/Metastatic Gastric/GEJ Cancer: Modeling Center of Excellence Practices
Format
Interactive Practice Guide
Time to Complete
1.00 hr(s).
Release Date
June 28, 2024
Expires On
June 28, 2025

Are you optimally treating your patients with gastric/gastroesophageal junction (GEJ) cancers per the latest evidence on selection of therapies?  Despite recent advancements in diagnosis of gastric/GEJ cancer, most cases are detected at advanced stages, resulting in poor outcomes. But advances have identified biomarkers that can offer more precise diagnostic and therapeutic approaches for gastric/GEJ cancer patients. In addition to HER2 and PD-L1 status, microsatellite instability (MSI) status should be determined for all patients. To optimize treatment, clinicians must not only have current knowledge of current biomarker testing and treatment selection, but also the operational frameworks to effectively translate this latest evidence into practice. Assess your current practices, review the latest evidence and best practices shared by leaders in the field, and create your own action plan to ensure your patients are benefitting from the latest advancements in care.

This activity is intended for medical oncologists, surgical oncologists, advanced practice clinicians, oncology nurses, and other members of the multidisciplinary/multispecialty team who treat patients with gastric/GEJ cancer.

Survival rates for patients with advanced/metastatic gastric/gastroesophageal junction (GEJ) cancers remain poor. Choice of first-line therapy is paramount, given that recurrence rates in gastric/GEJ cancer can be as high as 60%. Further, many patients with gastric/GEJ cancer fail to receive more than one line of therapy despite evidence that eligible patients who receive second-line therapy have improved survival. The treatment of advanced/metastatic gastric/GEJ cancer is increasingly complex with a number of novel targets and therapies. Oncologists and the multidisciplinary team face challenges in keeping pace with the latest clinical trial developments, therapy approvals, and potential adverse events.

Upon completion of this activity, learners will be able to:
•Develop models for early and effective biomarker testing 
•Assess the most recent evidence with selecting and sequencing treatments 
•Create appropriate gastric/GEJ cancer treatment plans that implement the latest data and recommendations 
•Incorporate multidisciplinary strategies to manage potential gastric/GEJ cancer treatment-related adverse events

Provided by The University of Chicago Pritzker School of Medicine and the Academy for Continued Healthcare Learning (ACHL).

Supported by educational grants from Merck & Co., Inc. and Astellas Pharmaceuticals.

On October 18, 2024, zolbetuximab received approval for use in combination with fluoropyrimidine- and platinum-containing chemotherapy for first-line treatment of adults with locally advanced unresectable or metastatic HER2-negative gastric/GEJ adenocarcinoma whose tumors are Claudin18.2 positive as determined by FDA-approved test. 

Manish A. Shah, MD, FASCO
Bartlett Family Professor of Gastrointestinal Oncology
Chief, Solid Tumor Oncology 
Weill Cornell Medicine
New York, NY 

Geoffrey Ku, MD 
Memorial Sloan Kettering Cancer Center 
New York, NY

The University of Chicago Pritzker School of Medicine and the Academy for Continued Healthcare Learning (ACHL) require that the faculty participating in an accredited continuing education activity disclose all affiliations or other financial relationships within 24 months (1) with the manufacturers of any commercial product(s) and/or provider(s) of commercial services discussed in an educational presentation and (2) with any ineligible companies. All relevant financial relationships have been mitigated prior to this activity. 
The following financial relationships have been provided:

Manish A. Shah, MD FASCO
Sources of Funding for Research: Bristol Meyers Squibb, Merck & Co., Oncolys BioPharma, Inc.  

Geoffrey Ku, MD  
Sources of Funding for Research: AstraZeneca, Bristol Meyers Squibb, CARsgen, Daiichi Sankyo, I-MAB BioPharma, Jazz Pharmaceuticals, Merck & Co. Inc., Oncolys BioPharma, Pieris Pharmaceuticals, Inc., Triumvira, Zymeworks  
Consulting Agreements: Astellas, AstraZeneca, Bayer, Bristol Meyers Squibb, Daiichi Sankyo, I-MAB BioPharma, Jazz Pharmaceuticals, Merck & Co. Inc., Pieris Pharmaceuticals, Inc., Zymeworks 

Discussion of Off-Label, Investigational, or Experimental Drug/Device Use: Agents under investigation for claudin 18.2- and FGFR2b-positive tumors

University of Chicago staff members, ACHL staff members, and others involved with the planning, development, and review of the content for this activity have no relevant affiliations or financial relationships to disclose.

The content for this activity was developed independently of any ineligible company. All materials are included with permission. The opinions expressed are those of the faculty and are not to be construed as those of the publisher or grantor(s).

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Recommendations involving clinical medicine in a continuing medical education (CME/CE) activity must be based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients. All scientific research referred to, reported, or used in CME/CE in support or justification of a patient care recommendation must conform to the generally accepted standards of experimental design, data collection, and analysis.

This CME/CE activity might describe the off-label, investigational, or experimental use of medications and/or devices that may exceed their FDA-approved labeling. Physicians should consult the current manufacturers’ prescribing information for these products. The University of Chicago Pritzker School of Medicine and ACHL require speakers to disclose that a product is not labeled for the use under discussion.

This activity will take approximately 60 minutes to complete. To receive credit, learners are required to complete the pretest, view the online activity, and complete the posttest and evaluation. To receive credit, 75% must be achieved on the posttest. A certificate will be immediately available. There is no fee to participate in the activity or for the generation of the certificate.



The University of Chicago Pritzker School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Chicago Pritzker School of Medicine designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physician assistants, nurse practitioners, and nurses may participate in this educational activity and earn a certificate of completion as AAPA, AANP, and ANCC accept AMA PRA Category 1 Credits™ through their reciprocity agreements.

Completion of this activity, including the pretest, posttest, and follow-up assessments, qualifies as a medium weight MIPS improvement activity under MACRA and can be claimed as completion of IA_PSPA 28 of an Accredited Safety or Quality Improvement Program in the Quality Payment Program. Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website. You will receive additional information after completing the activity and receiving your certificate via email.

McKenna Reinhard
mreinhard@achlcme.org
(773)714-0705 ext. 121
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