Hot Topics in Oncology – Focus on the Immune Checkpoint Inhibitors (ICIs)
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Immune checkpoint inhibitors (ICIs) continue to break ground in a multitude of cancer types. With ever-evolving data and recommendations, oncology clinicians must keep pace with the latest ICI updates.
This recorded CME-certified session tackles questions surrounding topics related to immune checkpoint inhibitors with discussion on:
- Role of biomarkers with ICI selection and monitoring
- Latest expanded ICI indications
- Immune-related adverse events
This session also features Q&A from the meeting highlighting common questions related to immunooncology (IO) treatments.
On July 26, 2021, the FDA approved pembrolizumab for high-risk, early-stage, TNBC in combination with chemotherapy as neoadjuvant treatment, and then continued as a single agent as adjuvant treatment after surgery.
On August 10, 2021, the FDA approved combination lenvatinib plus pembrolizumab for first-line treatment of adult patients with advanced renal cell carcinoma.
On August 18, 2021, the FDA granted accelerated approval to dostarlimab-gxly for dMMR recurrent or advanced solid tumors that have progressed on or following prior treatment and who have no satisfactory alternative treatment options
On August 20, 2021, the FDA approved adjuvant nivolumab in patients with urothelial carcinoma who are at a high risk of recurrence following radical resection regardless of previous treatment with neoadjuvant chemotherapy, nodal involvement, or PD-L1 status.
On October 13, 2021, the FDA approved pembrolizumab in combination with chemotherapy, with or without bevacizumab, for patients with persistent, recurrent, or metastatic cervical cancer whose tumors express PD-L1.
On October 15, 2021, the FDA approved atezolizumab as adjuvant treatment following resection and platinum-based chemotherapy in patients with stage II to IIIA NSCLC whose tumors have PD-L1 expression on ≥1% or greater of tumor cells.
On November 17, 2021: The FDA has approved pembrolizumab for the adjuvant treatment of patients with renal cell carcinoma at intermediate-high or high risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions.
On January 26, 2022, the FDA approved the T cell receptor therapeutic, tebentafusp-tebn for unresectable or metastatic unveal melanoma.
On February 28, 2022: Ciltacabtagene autoleucel is now approved for patients with relapsed or refractory multiple myeloma.
Update March 4, 2022: nivolumab with platinum-doublet chemotherapy is now approved for adult patients with resectable NSCLC in the neoadjuvant setting.
Update March 18, 2022: The FDA has approved the fixed-dose combination of relatlimab plus nivolumab for the treatment of adult and pediatric patients greater than or equal to 12 years old with unresectable or metastatic melanoma.
Update May 27, 2022: The FDA has approved nivolumab in combination with fluoropyrimidine- and platinum-containing chemotherapy and nivolumab plus ipilimumab as a first-line treatment for adult patients with unresevtable advanced or metastatic esopageal squamous cell carcinoma regardless of PD-L1 status.
• Optimize ICI selection by incorporating the latest data and recommendations with available biomarkers
• Assess the pivotal trial data with the latest expanded indications with the ICIs
• Incorporate strategies to best mitigate immune-related adverse events
• New 2021 ICI approvals
• Immune-related adverse events (irAEs)
• New and emerging immunooncology strategies
• Q&A session
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Associate Professor of Medicine of Hematology/Oncology
Vanderbilt University Medical Center
The Academy for Continued Healthcare Learning (ACHL) requires that the faculty participating in an accredited continuing education activity disclose all affiliations or other financial relationships (1) with the manufacturers of any commercial product(s) and/or provider(s) of commercial services discussed in an educational presentation and (2) with any commercial supporters of the activity. All conflicts of interest have been mitigated prior to this activity.
The following financial relationships have been provided: