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Out-of-the-Box Solutions for Building Clinical Capacity in Community Settings to Improve Standardized ERBB2 (HER2) Testing in NSCLC

Strategies for Improving ERBB2 (HER2) Testing in NSCLC Within Community Settings
Strategies for Improving ERBB2 (HER2) Testing in NSCLC Within Community Settings
Interactive Practice Guide

The pace at which targetable tumor-specific molecular alterations have been identified over the past decade have ushered in an era of precision oncology, yielding significant insights into the diversity of cancer, offering diagnostic and prognostic benefits, and guiding therapy selection. Indeed, guidelines emphasize that comprehensive biomarker testing should be conducted to identify actionable mutations in non-small-cell lung cancer (NSCLC), including ALK, EGFR, KRAS, MET, RET, and ERBB2 (HER2). These tests guide the selection of targeted therapies that can inhibit oncogenic pathways directly implicated in tumor growth and progression. However, comprehensive molecular testing continues to be underused, especially in community hospital settings. Underlying reasons are many and varied, and include lack of clinical knowledge, lack of multidisciplinary support in the interpretation of test results, shortcomings in tissue samples, lack of access to tests, reimbursement challenges, and turnaround times. 

Quality improvement (QI) programs are well suited to facilitate adoption of system-level solutions to improve guideline recommended testing of patients with NSCLC, including in patients with HER2 (ERBB2) mutations; To improve guideline recommended testing of patients with NSCLC, including in patients with HER2 (ERBB2) mutations, implementation-focused educational programs facilitating system- and process-related changes along with formalized training cascades are key to mitigating barriers. This interactive practice guide offers interventions for both team training and infrastructure building in a cost effective and high impact way. Learners can identify solutions most relevant to their scope of practice and areas of need.

Don’t delay! Start improving your NSCLC biomarker testing to optimize treatment processes and practices now!

Faculty: Christine Bestvina, MD; Melissa Tjota, MD, PhD

Release Date: April 01, 2026

Expiration Date: April 01, 2027

Toolkit: Out-of-the-Box Solutions for Building Clinical Capacity in Community Settings to Improve Standardized ERBB2 (HER2) Testing in NSCLC
Toolkit: Out-of-the-Box Solutions for Building Clinical Capacity in Community Settings to Improve Standardized ERBB2 (HER2) Testing in NSCLC
Digital Quality Improvement

Faculty: Christine Bestvina, MD; Melissa Tjota, MD, PhD

Release Date: April 01, 2026

Expiration Date: April 01, 2028

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